The causal relationship between grain intake and insomnia:a Mendelian randomization study
Xu Shuai
Wang Zilin
Zhang Jindan
Zhu Lili
Zhang Ye
Zhang Xinye
Zhang Hongshi
Abstract：Objective To investigate the causal relationship between grain intake and insomnia using Mendelian randomization(MR).Methods Single nucleotide polymorphisms(SNPs)associated with grain intake were obtained from published genome-wide association studies(GWAS)and used as instrumental variables.The inverse-variance weighted(IVW)method was ap-plied to assess causality.Genetic heterogeneity was evaluated using Cochran's Q test,horizontal pleiotropy was tested via MR-PRESSO and MR-Egger regression,and sensitivity analysis was conducted using leave-one-out analysis.Results IVW analysis revealed that higher grain intake reduces the risk of insomnia(OR=0.91,95％CI:0.86-0.97,P=0.004),indicating a pro-tective effect.Each additional one-bowl weekly increase in grain intake was associated with a 9％reduction in insomnia risk.Conclusion A negative causal relationship exists between grain intake and insomnia.Increased grain consumption may modu-late sleep regulation and reduce insomnia risk.
Keywords：Grain intakeInsomniaMendelian randomizationCausal relationship
Publication Date：2025-02-20
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：8( 46-53 )