Interference of paracetamol with six clinical biochemical tests
Zhao Junmei
Lu Qun
Yin Yuan
Wang Zhengyin
Abstract：Objective To assess the interference of paracetamol with six clinical biochemical tests.Methods According to the Clinical&Laboratory Standards Institute(CLSI)EP7-A3 document,the paired difference test and dose-effect test were used to evaluate the interference of paracetamol on alanine aminotransferase(ALT),aspartate aminotransferase(AST),creatinine(Cr),uric acid(UA),triglyceride(TG),and glucose(Glu)tests.Results The paired difference test showed that 40 mL/L paracetamol caused positive interference in ALT,AST,Cr,and UA tests,negative interference in the Glu test,and no interference in the TG test.The dose-effect results indicated nonlinear interference of paracetamol in ALT,AST,Cr,UA,and Glu tests.Conclusion Paracetamol interferes with ALT,AST,Cr,UA,and Glu biochemical tests.
Keywords：ParacetamolDrug interferenceBiochemical parameters
Publication Date：2024-11-20
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 33-36 )