Correlation between complements C4 and C5b-9 expression levels and mid-term MACE occurrence in patients with unstable angina pectoris after percutaneous coronary intervention
Fan Meng
Zhang Hui
Zhang Shuxia
Wang Yunbao
Zhao Dongsheng
Abstract：Objective To investigate the correlation between complements C4 and C5b-9 expression levels and mid-term ma-jor adverse cardiovascular events(MACE)in patients with unstable angina pectoris(UAP)after percutaneous coronary in-tervention(PCI).Methods A total of 200 UAP patients undergoing PCI at our hospital from May 2021 to May 2022 were included.Preoperative serum levels of C5b-9 and C4 were measured using enzyme-linked immunosorbent assay(ELISA).The incidence of MACE was evaluated during the mid-term follow-up period(24 hours to 6 months post-PCI).Results Fol-low-up results showed that 14 patients experienced MACE,while 186 did not.The MACE group had significantly higher C4 levels and lower C5b-9 levels compared to the non-MACE group(P<0.05).Pearson linear correlation analysis revealed a positive correlation between C5b-9 levels and mid-term MACE occurrence(P<0.05).Receiver operating characteristic(ROC)curve analysis demonstrated that the sensitivity and specificity for predicting MACE were 57.50%and 57.10%for C4(AUC=0.575,cutoff=172.91 mg/L),and 86.00%and 85.70%for C5b-9(AUC=0.911,cutoff=431.117 μg/L).Based on cutoff values,patients were stratified into high-C4(≥172.91 mg/L,n=39)and low-C4(<172.91 mg/L,n=161)groups,and high-C5b-9(≥431.117 μg/L,n=172)and low-C5b-9(<431.117 μg/L,n=28)groups.The mean MACE occurrence time was shorter in the high-C4 group(5.03±0.03 months)than in the low-C4 group(5.55±0.09 months;Log-Rank χ2=63.397,P<0.05).Conversely,the high-C5b-9 group had a longer mean MACE occurrence time(5.69±1.06 months)than the low-C5b-9 group(5.04±1.07 months;Log-Rank χ2=6.143,P=0.013).Conclusion Complements C4 and C5b-9 expression levels are associated with mid-term MACE occurrence in UAP patients post-PCI and may serve as predictive biomarkers for MACE.
Keywords：Complement C4C5b-9Unstable angina pectorisPercutaneous coronary interventionMid-termMajor ad-verse cardiovascular events
Publication Date：2024-11-20
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：5( 28-32 )