A study of the clinical characteristics of depression in Parkinson's disease and its correlation with norepinephrine
Liu Qi
Wang Zengshuai
Yang Hanxuan
Ta Mila
Feng Caixia
Abstract：Objective To explore the clinical characteristics of depression Parkinson's disease(PD),risk factors and their cor-relation with norepinephrine.Methods 105 PD patients who attended the inpatient and outpatient departments of the Sec-ond Affiliated Hospital of Baotou Medical College from January 2021 to December 2022 were included in the study.The se-verity of depression was assessed based on the 17-item version of the Hamilton Depression Scale(HAMD),and they were categorized into 62 cases in the PD depressed group and 43 cases in the PD non-depressed group.All enrolled patients were recorded in detail of past history,clinical data,scale assessment,and peripheral blood norepinephrine level was detected.Results Compared with the PD non-depressed group,patients in the PD depressed group were more female,had more Pos-tural Instability/Gait Disorders(PIGD)type of PD,and had a higher H-Y staging,UPDRS-Ⅲ score,PIGD domain score,HAMD score,higher single-day levodopa equivalent dose,and lower norepinephrine level,and the difference was statisti-cally significant(P<0.05).Percentage of each factor of HAMD scale in PD depressed patients:compared with the stand-ard percentage of each factor,the percentage of blocking(0.24 vs.0.35)and anxiety/somatization factors(0.36 vs.0.39)was increased in PD depressed patients,and the percentage of the factors of cognitive impairment(0.24 vs.0.12)and weight loss(0.04 vs.0.02)was decreased(P<0.05).Multifactorial logistic regression analysis was performed,showing an increase in patients with PIGD-type PD(OR=3.363,95%CI:1.235-9.162,P=0.018),UPDRS-Ⅲ score(OR=1.076,95%CI:1.009-1.148,P=0.026),and norepinephrine(OR=0.999,95%CI:0.997-1.000,P=0.032)were risk factors for depression in PD.The norepinephrine level in PD patients was negatively correlated with HAMD score(r=-0.531)and UPDRS-Ⅲ score(r=-0.424)(both P<0.01).The ROC curve showed a high assessment value for the oc-currence of depression in PD patients when the UPDRS-Ⅲ score was≥23.5 and norepinephrine was≤1.47 nmol/L.Conclu-sion PD depression is dominated by blocking and anxiety/somatization symptom disorders,and patients with PIGD type PD,increased UPDRS-Ⅲ scores,and decreased norepinephrine are risk factors for PD depression,and dysregulation of nor-epinephrine transmitters is involved in the onset and development of PD depression.
Keywords：Parkinson's diseaseDepressionNorepinephrineRisk factors
Publication Date：2024-12-28
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：6( 103-108 )