Research progress on the mechanism of Th17/Treg imbalance in sepsis-induced acute respiratory distress syndrome
Yang Xue
Han Hao
Chen Keyi
Wang Xin
Ke Xiaoxian
Feng Xuan
Liu Xiaoping
Zhao Jin
Yang Yanxia
Abstract：Acute respiratory distress syndrome(ARDS)is a type of acute respiratory failure caused by non-cardiogenic pul-monary or extrapulmonary injury factors,characterized by diffuse alveolar inflammation and edema.Sepsis is a major trigger of ARDS and is associated with high mortality rates.Imbalanced inflammatory responses are a key pathogenic mechanism,and the imbalance between helper T cells 17(Th17)and regulatory T cells(Treg),which are critical pro-inflammatory/an-ti-inflammatory immunomodulatory cells,plays a pivotal role in the progression of ARDS.This review focuses on exploring the mechanisms of Th17/Treg imbalance in sepsis-induced ARDS,aiming to provide new immunomodulatory targets for the clinical treatment of ARDS.
Keywords：Acute respiratory distress syndromeSepsisHelper T cells 17Regulatory T cells
Publication Date：2024-11-28
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：8( 112-119 )