Clinical efficacy and impact on anorectal manometry of biofeedback electrical stimulation combined with itopride hydrochloride in patients with chronic functional outlet obstruction constipation
Chen Jianxing
Zheng Yuanyuan
Zhuang Yunying
Chen Linghong
Wu Meiyu
Huang Yongde
Chen Xudong
Wu Meijuan
Abstract：Objective To explore the clinical efficacy and impact on anorectal manometry of biofeedback electrical stimulation combined with itopride hydrochloride in patients with chronic functional outlet obstruction constipation(CFOOC),aiming to provide a reference for the clinical treatment of such patients.Methods From January 2022 to March 2024,110 patients with CFOOC treated at our hospital were randomly divided into an observation group and a control group,each consisting of 55 cases,using the random number table method.The control group was treated with itopride hydrochloride,while the ob-servation group was treated with a combination of biofeedback electrical stimulation and itopride hydrochloride.The clinical efficacy and adverse reaction occurrence during the treatment period were compared between the two groups after one month of treatment.The anorectal manometry indices,rectal sensory function indices,and oxidative stress levels before and after treatment were also compared.Results The overall response rate of treatment in the observation group was significantly higher than that in the control group[98.18％(54/55)vs.85.45％(47/55);x2=4.356,P=0.037].No statistically sig-nificant difference was noted in the incidence of adverse reactions during the treatment period between the two groups(X2=0.484,P=0.487).Before treatment,there were no statistically significant differences in anal canal resting pressure,anal canal maximum contraction pressure,and anal canal maximum squeeze pressure levels between the two groups(P＞0.05);after one month of treatment,these levels were lower than before treatment in both groups,and the observation group had lower levels than the control group,with statistically significant differences(P＜0.05).Before treatment,there were no statistically significant differences in maximum tolerable volume,initial defecation sensation threshold,and defecation ur-gency threshold levels between the two groups(P＞0.05);after one month of treatment,these levels were lower than be-fore treatment in both groups,and the observation group had lower levels than the control group,with statistically signifi-cant differences(P＜0.05).Before treatment,there were no statistically significant differences in serum superoxide dis-mutase(SOD),malondialdehyde(MDA),and lipid peroxidation(LPO)levels between the two groups(P＞0.05).After one month of treatment,the serum SOD levels were higher than before treatment in both groups,with the observation group having higher levels than the control group,and the serum MDA and LPO levels were lower than before treatment,with the observation group having lower levels than the control group,with statistically significant differences(P＜0.05).Conclusion The combination of biofeedback electrical stimulation and itopride hydrochloride treatment can effectively allevi-ate the constipation symptoms of patients with CFOOC,significantly improve anorectal manometry,rectal sensory func-tion,and oxidative stress levels,and has good safety,holding promise for promotion and application in clinical practice.
Keywords：Biofeedback electrical stimulationItopride hydrochlorideChronic functional outlet obstruction constipationClinical efficacyAnorectal manometryRectal sensory functionOxidative stress
Publication Date：2024-07-28
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：6( 57-62 )