Analysis of clinical prognosis for radical surgery in patients with pT2-3N0-1M0 stage thoracic esophageal squamous cell carcinoma

Wu Yan; Zhang Dongmei; Wang Lingling; Sun Qingchao; Zhou Ye

doi:10.11986/j.issn.1673-873X.2023.12.006

Abstract：Objective To explore the postoperative prognosis and influencing factors of radical surgery in patients with pT2-3N0-1M0 stage thoracic esophageal squamous cell carcinoma.Methods A total of 138 patients with pT2-3N0-1M0 stage thoracic esophageal squamous cell carcinoma who underwent radical surgery at the First Affiliated Hospital of Xinjiang Med-ical University from January 2017 to November 2019 were selected as participants.Clinical and follow-up data of all patients were retrospectively collected and analyzed.Patients were required to undergo follow-up examinations 3-6 months after surgery within the first year,followed by examinations every 6-12 months,and then once a year after 3 years.All patients were followed up until December 2022.The local recurrence,lymph node metastasis,and survival prognosis of the patients were statistically analyzed,and logistic regression analysis was used to identify factors influencing the prognosis of patients with this condition.Results Among the 138 patients,129 patients completed the follow-up,with a follow-up rate of 93.48％.Within 3 years after surgery,78 patients demonstrated poor prognosis and 51 patients demonstrated good progno-sis,resulting in a poor prognosis rate of 60.47％.No statistically significant differences were observed in age,gender com-position,tumor location,postoperative adjuvant chemotherapy,and histological differentiation between patients with differ-ent prognoses(P＞0.05).The proportion of patients with pT3 stage,pN1 stage,combined vascular tumor embolism,and tumor diameter＞3 cm was significantly higher in patients with poor prognosis than in those with good prognosis(P＜0.05).Logistic regression analysis showed that pT3 stage,pN1 stage,combined vascular tumor embolism,and tumor di-ameter＞3 cm were risk factors for poor prognosis in patients with esophageal squamous cell carcinoma(P＜0.05).Con-clusion The prognosis of patients with pT2-3N0-1M0 stage thoracic esophageal squamous cell carcinoma is closely correla-ted with pT and pN staging,combined vascular tumor embolism,and tumor diameter.pT3 stage,pN1 stage,combined vas-cular tumor embolism,and tumor diameter＞3 cm are risk factors for poor prognosis in patients with esophageal squamous cell carcinoma.Clinically,patients with these risk factors should be given attention and early intervention to reduce the risk of poor prognosis.