Effect of Edaravone combined with Gastrodin on cerebrovascular function in elderly hypertensive intracerebral hemorrhage patients

Wang Qiumeng; Jin Mingyue; Wang Wenjuan; Lin Xue

doi:10.11986/j.issn.1673-873X.2023.12.005

Abstract：Objective To investigate the effect of edaravone combined with gastrodin on cerebrovascular function in elderly hypertensive intracerebral hemorrhage patients.Methods A total of 102 elderly hypertensive intracerebral hemorrhage pa-tients admitted to Beijing Shijitan Hospital,Capital Medical University from January 2019 to September 2022 were selected and allocated to a control group(49 cases)and an observation group(53 cases)according to different treatment plans.The control group received intravenous infusion of edaravone,while the observation group received intravenous infusion of edara-vone combined with gastrodin.The cerebrovascular function,clinical efficacy,levels of inflammatory factors,hemorrhage volume,and occurrence of adverse reactions were compared between the two groups.Results Before treatment,no signifi-cant difference was observed in cerebrovascular mean flow velocity,mean flow rate,peripheral resistance,and dynamic re-sistance between the two groups(P＞0.05).After treatment,the cerebrovascular mean flow velocity and mean flow rate in both groups were higher than before treatment,and the observation group was higher than the control group;the peripheral resistance and dynamic resistance were lower than before treatment,and the observation group was lower than the control group,all with statistical significance(P＜0.05).The overall response rate of the observation group was significantly high-er than that in the control group[84.91％(45/53)vs.67.35％(33/49);x2=4.363,P=0.037].Before treatment,no significant difference was found in the levels of serum interleukin-6(IL-6),tumor necrosis factor-alpha(TNF-α),and high-sensitivity C-reactive protein(hs-CRP)between the two groups(P＞0.05).After treatment,the levels of serum hs-CRP,IL-6,and TNF-α in both groups were significantly lower than before treatment,and the observation group was significantly lower than the control group(P＜0.05).The difference in the incidence of adverse reactions during the treatment period be-tween the control group and the observation group was not statistically significant[12.24％(6/49)vs.9.43％(5/53);x2=0.209,P=0.647].Before treatment,there was no significant difference in hemorrhage volume between the two groups(P＞0.05).After treatment,the hemorrhage volume in both groups was significantly decreased,and the observa-tion group was significantly less than the control group(P＜0.05).Conclusion Edaravone combined with gastrodin dem-onstrates marked clinical efficacy in the treatment of elderly hypertensive intracerebral hemorrhage patients.It can effective-ly strengthen cerebrovascular function,and alleviate inflammatory reactions,with a high safety profile,providing certain guidance for clinical diagnosis and treatment.