Effect of BSA-based individualized contrast medium injection on image quality and examination accuracy in patients examined by CCTA

Liu Yue; Zhang Yanbin; Liang Ziyi

doi:10.11986/j.issn.1673-873X.2023.10.015

Abstract：Objective To investigate the effect of different contrast medium injection regimens on image quality and accuracy of coronary CT angiography(CCTA).Methods A total of 120 patients scheduled for CCTA from March 2020 to July 2022 were selected as the study participants by convenience sampling.They were allocated to the observation group and control group by a random number table,with 60 cases in each group.The control group received the injection regimen with a fixed dose and flow rate,and the observation group received the individualized injection regimen based on body surface area(BSA).The CT values of different measurement sites of the coronary artery,right ventricular and superior vena cava arti-fact grades,interventricular septum display scores,objective(contrast-to-noise ratio[CNR])and subjective indices of image quality scores,radiation doses,and iodine loads were compared between the two groups.The CCTA examination results were compared with the gold standard(clinical follow-up or coronary angiography)to evaluate the examination accuracy.Results No significant difference was observed in the CT values of the aorta and right coronary artery(RCA)between the two groups(P＞0.05).The CT values of the left main coronary artery(LM),left anterior descending artery(LAD),and left circumflex artery(LCX)in the observation group were greater than those in the control group(P＜0.05).The right ventricular and superior vena cava artifact grade and interventricular septum display scores in the observation group were su-perior to those in the control group(P＜0.05).The CNR in the observation group was greater than that in the control group(P＜0.05).The clarity,artifact,coronary artery display,and coronary artery branch visualization scores in the sub-jective image quality score in the observation group were not significantly different from those in the control group(P＞0.05).The CT dose index(CTDI),CT dose length product(DLP),effective radiation dose,and iodine load in the observa-tion group were less than those in the control group(P＜0.05).The diagnostic results of 57 patients in the observation group and 54 patients in the control group were consistent with the gold standard,and no significant difference was found in the diagnostic accuracy between the groups(P＞0.05).Conclusion The BSA-based individualized contrast medium injec-tion regimen can improve the image quality of CCTA examination and reduce the radiation dose and iodine load of patients compared with the traditional fixed dose and flow rate regimen,holding promise for a wider clinical application.