Effect of doxofylline combined with tiotropium bromide on serum APN NE and α1-AT levels in COPD patients

Pu Xiaojuan; Peng Fang; Zhao Qiquan; Chen Yuanting; Liu Meiting

doi:10.11986/j.issn.1673-873X.2023.10.007

Abstract：Objective This paper aims to investigate the effect of doxofylline combined with tiotropium bromide on serum ad-iponectin(APN),neutrophil elastase(NE),and α1-antitrypsin(α1-AT)levels in patients with chronic obstructive pulmo-nary disease(COPD).Methods Overall,110 patients with COPD admitted to Dazu Hospital of Chongqing Medical Univer-sity from Feb.2020 to May 2022 were selected as the study participants,who were assigned to the observation group(n=55)and the control group(n=55)by a random number table.The patients in the control group received tiotropium bromide;while the patients in the observation group,doxofylline combined with tiotropium bromide.The clinical efficacy,serum indicators,pulmonary function indicators,inflammatory indicators,and adverse reactions before and after treatment were compared between the two groups.Results The overall response rate of the observation group was significantly higher than that of the control group[96.36％(53/55)vs.80.00％(44/55);x2=7.066,P=0.008].Before treatment,no sig-nificant difference was observed in forced expiratory volume in 1 second(FEV1),predicted percentage of forced expiratory volume in 1 second(FEV1％pred),and ratio of forced expiratory volume in 1 second to forced vital capacity(FEV1/FVC)levels between the two groups(P＞0.05);FEV1,FEV1％pred and FEV1/FVC levels in the two groups showed a signifi-cant increase after treatment,and the observation group was significantly higher than the control group(P＜0.05).Before treatment,no significant difference was found in serum APN,NE,and α1-AT levels between the two groups(P＞0.05);serum APN and α1-AT levels in the two groups were significantly increased after treatment,and the observation group was significantly higher than the control group(P＜0.05);serum NE levels were significantly declined,and the observation group was significantly lower than that in the control group(P＜0.05).Before treatment,no significant difference was de-tected in serum interleukin-6(IL-6),interleukin-8(IL-8),and tumor necrosis factor-α(TNF-α)levels between the two groups(P＞0.05);serum IL-6,IL-8 and TNF-α levels in the two groups were decreased after treatment,and the observa-tion group was lower than the control group,with statistical significance(P＜0.05).The incidence of adverse reactions in the observation group and the control group was not statistically significant[14.55％(8/55)vs.18.18％(10/55),x2=0.266,P=0.606].Conclusion Doxofylline in combination with tiotropium bromide in the treatment of COPD patients is beneficial to promoting pulmonary function,potentiating serum indicators levels,and reducing the inflammatory response,with high safety profiles.