Brain structural damage,brain frailty,and brain age in the prognostic assessment of ischemic stroke
LI Jianan
ZHAO Sijia
ZHU Wusheng
CHENG Xiaoqing
Abstract：Functional recovery after ischemic stroke exhibits considerable interindividual variation that conventional clinical measures often fail to fully explain.Advances in artificial intelligence have enabled novel neuroimaging-based approaches.Metrics such as brain structure damage,brain frailty,and brain age offer new perspectives for assessing brain health reserve and predicting outcomes.This review systematically outlines the definitions,assessment methods,and clinical relevance of brain structure damage,brain frailty,and brain age,and examines their interrelationships.A deeper understanding of these relationships may allow more precise interpretation of individual differences in post-stroke recovery,providing valuable insights for establishing a multidimensional prognostic prediction system and advancing precision medicine in stroke care.
Keywords：Ischemic strokeBrain structureBrain frailtyBrain ageMagnetic resonance imaging
Publication Date：2026-03-15
Online Publishing Date：2026-04-01(First online date of this platform, not the publication date of the document)
Pages：5( 185-189 )