Advances in the application of multimodal MRI to fetal and pediatric brain development and neurodevelopmental disorders
ZHANG Yueyue
DONG Suzhen
Abstract：Fetal and childhood periods are critical stages of early brain development.The advancement of multimodal MRI technologies has provided important tools for investigating brain development and neurodevelopmental disorders.Structural MRI can reveal brain volume and cortical developmental patterns;diffusion MRI can delineate white matter tracts and the development of neural networks;blood oxygenation level dependent(BOLD)functional MRI can elucidate the formation and abnormalities of functional networks;and MRS can reflect the metabolic states of the brain.This review summarizes recent progress in the use of multimodal MRI to investigate fetal and pediatric brain development,as well as its applications in the early diagnosis,disease subtyping,and exploration of comorbidity mechanisms of neurodevelopmental disorders such as attention-deficit/hyperactivity disorder,autism spectrum disorder,and Tourette syndrome.
Keywords：Magnetic resonance imagingBrain developmentNeurodevelopmental disordersEarly diagnosisComorbidity
Publication Date：2025-11-15
Online Publishing Date：2025-12-15(First online date of this platform, not the publication date of the document)
Pages：6( 672-677 )