Application of hypoxia-related functional MRI in neoadjuvant therapy for breast cancer
ZHAO Ruimeng
DU Siyao
ZHANG Lina
Abstract：The hypoxic tumor microenvironment is a key factor affecting the efficacy of neoadjuvant therapy(NAT)in breast cancer,and its heterogeneity complicates treatment outcomes.Functional magnetic resonance imaging(fMRI)techniques enable noninvasive quantification of tumor hypoxia,facilitating hypoxia assessment and therapy optimization.This approach helps to avoid ineffective chemotherapy toxicity,reduce adverse reactions,and guide treatment adjustment.This review summarizes the mechanisms of hypoxia,relevant fMRI principles,and the applications of fMRI-based hypoxia assessment,monitoring,and therapeutic assistance in breast cancer NAT.
Keywords：Breast cancerNeoadjuvant therapyFunctional magnetic resonance imagingHypoxia
Publication Date：2025-11-15
Online Publishing Date：2025-12-15(First online date of this platform, not the publication date of the document)
Pages：6( 640-645 )