Research progress of time-dependent diffusion magnetic resonance imaging in tumors
GONG Hao
LONG Ling
WANG Xiaoxia
ZHANG Jiuquan
Abstract：Time-dependent diffusion MRI(TDDMRI)is an MRI technique that combines oscillating gradient spin-echo(OGSE)sequences with pulsed gradient spin-echo(PGSE)sequences.It can comprehensively capture the time-dependent characteristics of water molecule diffusion and generate quantitative microstructural parameters,such as intracellular volume fraction(fin),cell diameter(d),and cell density,through modeling.This allows for non-invasive quantification of tumor microstructure.This paper briefly introduces the principles of TDDMRI and commonly used models,and systematically reviews its recent applications in human tumors,including differential diagnosis,treatment response prediction,prognosis evaluation,precision diagnosis,and risk stratification.
Keywords：Oscillating gradient spin-echoTime-dependent diffusionMagnetic resonance imagingTumorMicrostructural parameters
Publication Date：2025-09-15
Online Publishing Date：2025-10-13(First online date of this platform, not the publication date of the document)
Pages：5( 588-592 )