Neurovascular coupling and cognitive impairment:advances in multimodal imaging research
LI Xiaoxuan
E Renjie
LYU Peiyuan
MA Haoyuan
Abstract：Neurovascular coupling(NVC)refers to the brain's regulatory capacity to adjust cerebral blood flow in response to neuronal activity,representing a coordinated function between neural activity and hemodynamics.Impairment in NVC diminishes connectivity between distinct brain regions,thereby impairing cognitive function.Currently,various neuroimaging techniques including arterial spin labeling,resting-state functional MRI,and functional near-infrared spectroscopy are employed to evaluate NVC function.These methods have confirmed that declines in NVC are closely linked to cognitive impairments in conditions such as vascular cognitive impairment,Alzheimer's disease,diabetic cognitive decline,and cognitive deficits in end-stage renal disease patients.This review aims to provide an overview of recent advances in neuroimaging research on the relationship between NVC and cognitive disorders.
Keywords：Neurovascular couplingCognitive impairmentMagnetic resonance imagingArterial spin labelingFunctional near-infrared spectroscopy
Publication Date：2025-09-15
Online Publishing Date：2025-10-13(First online date of this platform, not the publication date of the document)
Pages：6( 561-566 )