Research progress of ultrasound microbubbles in targeted therapy for cancer therapy-related cardiotoxicity
ZHUANG Haiming
WANG Wuwan
WANG Yong
Abstract：Cancer therapies may induce varying degrees of cardiac injury,leading to cancer therapy-related cardiovascular toxicity(CTR-CVT)that significantly impacts patient prognosis and long-term survival.Ultrasound microbubbles,as novel non-viral targeted delivery vehicles,exhibit unique physical properties,excellent biocompatibility,and ultrasound-triggered cavitation effects,demonstrating promising potential for CTR-CVT-targeted therapy.This review summarizes ultrasound microbubble characteristics and targeting mechanisms,with focus on recent advances in microbubble-mediated gene transfection and targeted drug delivery for systemic CTR-CVT treatment.
Keywords：Ultrasound microbubblesCancerTargeted therapyGene therapyDrug delivery
Publication Date：2025-07-15
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：5( 379-383 )