Application of radionuclides in the integrated diagnosis and treatment of radioiodine-refractory differentiated thyroid cancer
CHEN Qiaotong
FANG Chen
Abstract：Early and comprehensive diagnosis and treatment are crucial for improving the prognosis of radioiodine-refractory differentiated thyroid cancer(RAIR-DTC).Radiopharmaceuticals targeting emerging probes,such as Arg-Gly-Asp,somatostatin receptors,prostate-specific membrane antigen,and fibroblast activation protein,can be used for the non-invasive evaluation of the biological characteristics of RAIR-DTC.These probes assist in tumor diagnosis and staging and play an important role in predicting disease progression and formulating treatment strategies.This review summarizes recent advancements in the integrated strategy of radioisotope-based diagnosis and therapy for RAIR-DTC.
Keywords：Thyroid cancerNuclear medicineRadioactive nuclidesPositron emission tomographyTomographyX-ray computedSingle-photon emission computed tomographyTheranostics
Publication Date：2025-05-15
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：6( 349-353,358 )