Resting-state functional MRI activation likelihood estimation meta-analysis of abnormal spontaneous brain activity in sensorineural hearing loss
WANG Aijie
HUANG Ranran
WANG Chunye
LI Yunxin
BAO Xianghua
ZHANG Guowei
Abstract：Objective To investigate the characteristics of altered spontaneous brain activity in patients with sensorineural hearing loss(SNHL)using activation likelihood estimation(ALE)meta-analysis,and to further understand the potential neural mechanisms of brain functional impairment and remodeling in SNHL.Methods A systematic search was conducted up to August 21,2023,in Web of Science,PubMed,CNKI,Wanfang Med Online,and the Chinese Medical Journal Full-text Database for studies applying regional homogeneity(ReHo)and amplitude of low-frequency fluctuation/fractional ALFF(ALFF/fALFF)analyses to evaluate brain functional changes in SNHL patients.After applying inclusion and exclusion criteria,studies were included in a meta-analysis using the ALE method to identify brain regions with abnormal spontaneous neural activity in SNHL patients.Results A total of 22 articles comprising 29 studies were included,involving 736 cases of SNHL and 487 controls.Among these,11 studies used ReHo and 18 studies used ALFF/fALFF.A combined analysis of ReHo/ALFF/fALFF without differentiating the side of deafness revealed increased spontaneous brain activity in the left medial dorsal thalamus,and decreased activity in the left superior temporal gyrus,left opercular part of the inferior frontal gyrus,and left dorsolateral prefrontal cortex.Separate ALE analyses for left-sided and right-sided SNHL patients,as well as separate analyses using ReHo or ALFF/fALFF methods,did not identify any significantly altered brain regions.Conclusion The ALE meta-analysis confirms that SNHL patients exhibit abnormal spontaneous activity in multiple brain regions.These findings help elucidate the patterns and characteristics of brain functional damage and remodeling associated with SNHL,providing important evidence for future clinical assessment and treatment planning.
Keywords：Sensorineural hearing lossResting state functional magnetic resonance imagingActivation likelihood estimationSpontaneous brain activity
Publication Date：2025-05-15
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：7( 270-276 )