Research progress on amyloid-related imaging abnormalities in early Alzheimer's disease treated with Aβ monoclonal antibody
CHEN Zongqin
BAO Yifang
LI Yuxin
Abstract：Amyloid-related imaging abnormalities(ARIA)are among the most common adverse reactions during Aβmonoclonal antibody treatment for early Alzheimer's disease(AD).Magnetic resonance imaging(MRI)serves as a crucial tool tool for monitoring the occurrence of ARIA and assessing its severity throughout the treatment process.This paper provides a detailed overview of the mechanisms of ARIA,its imaging manifestations,and severity grading.Additionally,a comprehensive standard MRI examination protocol and monitoring workflow are proposed based on clinical practice experience.The study also highlights the critical role of imaging monitoring in guiding clinical medication for AD patients.
Keywords：AmyloidAlzheimer's diseaseAβ monoclonal antibodyMagnetic resonance imaging
Publication Date：2025-01-14
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：5( 59-63 )