Preliminary application of quantitative susceptibility mapping in evaluating pathological T staging,vascular and nerve invasion in rectal cancer
ZHANG Haini
LIU Zhongxiao
SUN Xiaoling
LI Keke
MENG Yankai
ZHUANG Yinping
WU Peng
XU Kai
Abstract：Objective To explore the value of quantitative susceptibility mapping(QSM)in assessing pathological T staging(pT),vascular invasion,and neural invasion in rectal cancer.Methods Data from 29 rectal cancer patients confirmed by pathology and undergoing preoperative QSM examination were retrospectively analyzed.According to pathological results,patients were divided into pT1-2(n=13)and pT3-4(n=16)groups based on pT staging,vascular invasion-positive(n=9)and-negative(n=20)groups,and neural invasion-positive(n=3)and-negative(n=26)groups.QSM images were processed on the MATLAB version 2018b platform,and the QSM-weighted images were imported into Fire Voxel build 394D software( segmentation.Histogram parameters of tumor susceptibility were automatically generated by the software.Mann-Whitney U tests were used to compare tissue susceptibility values between groups.Results The tissue susceptibility values at the 60th,70th,80th,and 90th percentiles were significantly higher in the pT3-4 group compared to the pT1-2 group(all P＜0.05).Similarly,vascular invasion-positive groups had significantly higher susceptibility values at these percentiles than vascular invasion-negative groups(all P＜0.05).No significant differences in susceptibility values were observed between neural invasion-positive and-negative groups(all P＞0.05).Conclusions QSM technology can be applied to rectal cancer research.Quantitative susceptibility values derived from QSM can reflect differences in rectal cancer pT staging,vascular invasion,and neural invasion.
Keywords：Rectal cancerMagnetic resonance imagingQuantitative susceptibility mappingHistogram analysis
Publication Date：2025-01-14
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：5( 15-19 )