Primary cervical NK/T-cell lymphoma with secondary peripheral nerve lymphomatosis:a case report
PANG Dinghua
XIAO Guoyou
CHAI Hua
Abstract：Objective To explore the imaging characteristics of primary cervical NK/T-cell lymphoma(NKTCL)with secondary peripheral nerve lymphomatosis,improving understanding of the disease and providing a reference for diagnosis and treatment decision.Methods A retrospective analysis was conducted on the clinical data,CT,MRI,and 18F-FDG PET/CT imaging findings of a patient with primary cervical NKTCL over a 9-month treatment period.Relevant literatures were also reviewed.Results The patient was admitted to hospital with vaginal fluid as the first symptom.Pre-treatment CT examination showed that the cervix was significantly enlarged,showing an irregular soft tissue mass with a size of approximately 8.4 cmx6.8 cmx8.3 cm and a uniform density.MRI displayed the cervical mass as isointense on T1WI,hyperintense on FS-T2WI and DWI,and hypointense on the corresponding ADC map.Enhanced scans showed marked homogeneous enhancement of the lesion,involving the upper vaginal segment,with multiple lymph nodes seen adjacent to the bilateral iliac vessels.PET/CT showed increased metabolism in cervical masses and left para-iliac lymph nodes.During treatment,PET/CT showed a significant reduction in metabolic activity and size,and the treatment was evaluated as achieving complete remission.Post-treatment,secondary neurolymphomatosis developed.PET/CT showed new hypermetabolic lesions in the right nerve root at the C2/3 level of cervical spine and along the course of the left sciatic nerve in the thigh.A biopsy of the C2/3 cervical spine nerve root lesion confirmed NKTCL infiltration.Conclusions The typical imaging manifestations of primary cervical NKTCL include a large,metabolically active but homogeneous mass with intact cervical mucosa.Imaging examination plays an important role in pre-treatment evaluation,accurate staging,treatment efficacy assessment,recurrence monitoring,and guiding biopsy site selection.
Keywords：Uterine neoplasmsNK/T-cell lymphomaNeurolymphomatosisTomographyX-ray computedMagnetic resonance imagingPositron emission tomography
Publication Date：2024-09-15
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 610-613 )