Advances in MRI research on chemotherapy-related cognitive impairment
HU Lanyue
YIN Xindao
CHEN Yuchen
Abstract：Chemotherapy-related cognitive impairment(CRCI)significantly impacts the life quality of cancer patients,and its neurobiological mechanism have garnered widespread attention.Multimodal magnetic resonance imaging(MRI),including structural MRI,functional MRI,arterial spin labeling(ASL),and magnetic resonance spectrum(MRS),can reflect the structural,functional,metabolic,and perfusion information of the brain,revealing the imaging mechanisms of the effects of chemotherapy drugs on cognitive function.Commonly used chemotherapeutic drugs,including anthracyclines,non-anthracyclines,and platinum-based compounds,can induce CRCI.This paper briefly reviews the potential molecular biology mechanisms of CRCI induced by different chemotherapy drugs,and summarizes the research progress of multimodal MRI technology in the structural and functional changes of the CRCI patients'brain.
Keywords：Chemotherapy-related cognitive impairmentMagnetic resonance imagingChemotherapeutic drugs
Publication Date：2024-07-15
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：7( 401-406,411 )