Multisystem involvement in patients with COVID-19 based on chest CT:a follow-up study
AN Ran
YAN Ying
WEI Wei
WEI Xuan
YANG Zhenghan
WANG Zhenchang
Abstract：Objective To investigate the changes of COVID-19 patients in lung lesion volume,thyroid,spleen,macrovascular,bone,and abdominal fat on chest CT images during follow-up.Methods Thirty-three patients of COVID-19(22 males and 11 females,mean age of 47.1±15.0 years)were retrospectively included.Chest CT scans were performed at baseline time and at 10 months later,measuring the volume of whole lung lesions,areas and mean densities of the bilateral lobes of thyroid gland,diameter of the main trunk of pulmonary artery,diameter of the main trunk of ascending aorta,short diameter of inferior vena cava,short diameter of the abdominal aorta,short diameter of inferior vena cava/short diameter abdominal aorta,thick diameter of spleen,longest diameter of spleen,mean density of the spleen,abdominal subcutaneous fat area,intra-abdominal fat area,mean liver fat,and mean density of thoracic spine.The above parameters between the baseline time and follow-up were compared using the paired-samples t-test or the Wilcoxon signed rank sum test.The intraclass correlation coefficient(ICC)was used to analyze the agreement between the 2 radiologists'measurements.Results The agreements were good(mean ICC>0.80)between the 2 observers'measurements of the macrovascular,thyroid,splenic,skeletal,and abdominal fat indices at the baseline time and follow-up.Comparing with the baseline data,the patients showed a decrease in the percentage of lung lesion volume,an increase in the diameter of the ascending aortic trunk,an increase in the thyroid area and a decrease in the mean thyroid density,a decrease in the spleen thickness and longest diameter,and a decrease in the mean density of the spleen at follow-up(all P<0.05).The remaining CT characteristics did not differ statistically between the baseline and follow-up measurements(all P>0.05).Conclusion Acute COVID-19,a disease affecting multiple organs,could cause structural alterations across various systems to the patients.
Keywords：Corona virus disease 2019TomographyX-ray computedChestMultiple organ involved
Publication Date：2024-03-15
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：7( 165-171 )