Influence of coronary calcification on the diagnostic accuracy of FFRCTin coronary artery disease
LIU Chunyu
LI Jianhua
TANG Chunxiang
ZHOU Changsheng
ZHANG Xiaolei
LU Mengjie
SUN Zhiyuan
LU Guangming
ZHANG Longjiang
Abstract：Objective To study the influence of coronary calcification on the diagnostic performance of fractional flow reserve(FFR)derived from coronary computed tomography angiography(CCTA)(FFRCT)in coronary artery disease. Methods CCTA and invasive coronary angiography data from 38 patients,including 50 target vessels,were retrospectively studied.The calcium scores of the 50 coronary arteries were measured by Agatston integral method,and patients were divided into two groups:A1 group(≤100)and A2 group(>100).The FFRCTvalues were measured by cFFR software.FFR derived from invasive coronary angiography and FFRCT values <0.8 were defined as lesion specific ischemia. The consistencies between FFRCTand FFR of the total,and A1 and A2 groups were calculated by using the correlation coefficient(ICC).With invasive FFR as reference standard,in a per-vessel basis,the accuracy,sensitivity,specificity,positive predictive value,and negative predictive value of the total,and A1 and A2 groups were calculated and Fisher's exact probability method was used to compare the differences between the two groups.Results ICC coefficient of FFRCTand FFR in the whole cohort was 0.771 (95%CI:0.597~0.870),in A1 group was 0.819(95%CI:0.633~0.910),and in A2 group was 0.649(95%CI:0.032~0.873).The diagnostic sensitivity, specificity, accuracy, positive predictive value, and negative predictive value of FFRCTwere 90.9%, 97.4%,96.0%,90.9%,and 97.4%,respectively for the whole cohort;85.7%,100%,96.9%,100%,and 96%,repectively,for the A1 group;and 100%,92.3%,94.1%,80%,and 100%,respectively,for the A2 group.There was no statistically significant difference in the diagnostic efficacy between the A1 and A2 groups(P>0.05).Conclusion FFRCThas good consistency with FFR in the evaluation of coronary artery stenosis.Calcification does not affect the diagnostic accuracy of FFRCT.
Keywords：Coronary artery diseaseCalcificationFractional flow reserveCT angiographyDiagnostic performance
Publication Date：2018-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：5( 277-281 )