Hemodynamical change in-borderline stenotic coronary artery assessed by FFRCTof CCTA
WANG Tongning
LIU Xin
YANG Lin
ZHANG Heye
XU Lei
FAN Zhanming
Abstract：Objective To evaluate the diagnostic value of coronary computed tomography angiography(CCTA)-fractional flow reserve(FFRCT)for hemodynamic changes in borderline stenotic coronary artery. Methods A total of 18 patients(13 male and 5 female,age range 49 to 76 years old)who underwent CCTA and invasive coronary angiography(ICA) were retrospectively studied.A maximal diameter reduction in coronary artery between 50% to 70% was regarded as target vessel,and fractional flow reserve(FFR)was measured by ICA,FFRCTwas calculated from data of CCTA in the selected target vessels.Regarding 0.80 as borderline value for both FFR and FFRCT.A value below 0.80 indicates hemodynamic change in the affected coronary artery and needs further treatment.The diagnostic accuracy,sensitivity,specificity,negative predictive value and positive predictive value of FFRCTand CCTA were calculated with FFR as golden standard.Diagnostic efficiency for coronary artery ischemia by CCTA stenosis and FFRCTwere compared using receiver operating characteristic(ROC) curve,Bland-Altman analysis and Spearman analysis.Results All of 27 vessels from 18 patients were eligible for analysis as target vessels.The diagnostic accuracy,sensitivity,specificity,positive predictive value and negative predictive value of FFRCTwere 88.9%,100%, 62.5%,86.4%,and 100%,respectively.FFR and FFRCTshowed intermediate correlation(r=0.663, P<0.001). Bland-Altman analysis presented good concordance between FFRCTand FFR(95% CI: -0.23 to 0.20), 96.3% of the points(26/27)fell in the 95% limit of agreement,and 3.7% of the points(1/27)fell out of the 95% limit of agreement.ROC curve indicated that AUC of FFRCTwas larger than that of CCTA(AUCs were 0.947,0.500,respectively;P<0.001). Conclusion For the evaluation of hemodynamic changes in borderline stenotic coronary artery, FFRCTis able to improve the diagnostic performance in comparison to CCTA alone.
Keywords：FFRCTBorderline stenotic coronary arteryHemodynamic changes
Publication Date：2018-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：5( 268-271,312 )