Comparative study of breast cancer shrinkage modes after neoadjuvant chemotherapy and corresponding morphological and molecular biological characteristics

SHAO Zhenzhen; WANG Ju; LIU Peifang; JI Yu; HOU Mingli

doi:10.19300/j.2018.L4405

Abstract：Objective To evaluate the breast cancer shrinkage modes after neoadjuvant chemotherapy and corre-sponding morphological and molecular biological characteristics.Methods There were 22 patients with histologically con-firmed breast cancer from January 2011 to December 2014 were collected. All patients were examined with dynamic en-hancement magnetic resonance imaging before neoadjuvant chemotherapy and after four cycles neoadjuvant chemotherapy,underwent radical mastectomy within two weeks after neoadjuvant chemotherapy. The correlation breast cancer shrinkage mode with lesion subtypes and chemotherapy reaction classification and molecular biological characteristics were analyzed with independent sample t test and the Fisher's exact test, respectively. Results Of 22 invasive ductal carcinoma, after neoadjuvant chemotherapy,14 patients presented concentric shrinkage,8 patients presented multi-concentric shrinkage.The cancer shrinkage proportion of the concentric group and multi-concentric group were 71.8%±28.3% and 38.7%±24.8%,re-spectively.There was significant difference in shrinkage volume between concentric group and multi-concentric group (t=2.757,P=0.012).The tumors with concentric shrinkage on MRI showed more mass lesions (11/14,78.6%)and the tumors with multi-concentric shrinkage showed more nonmass lesions(6/8,75%)after neoadjuvant chemotherapy,which was signifi-cant between the 2 groups (P=0.026).There were no significant differences in chemotherapy reaction classification,estrogen receptor(ER),progesterone receptor(PR),human epidermalgrowth factor receptor-2(HER2),p53,Ki-67,and molecular types between breast cancer shrinkage modes (P>0.05). Conclusions The breast cancer shrinkage modes after neoadjuvant chemotherapy correlate with morphology characteristics of breast cancers before neoadjuvant chemotherapy.The tumors with concentric shrinkage on MRI present more mass lesions and the tumors with multi-concentric shrinkage present more non-mass lesions.