Advances of new imaging technologies in evaluating efficacy of drugs for treatment of osteoporosis
ZHANG Xueli
TANG Guangyu
Abstract：Osteoporosis (OP) is a systemic metabolic disease, which is characterized by loss of bone strength and increased susceptibility fractures. The number of OP patients in our country increases gradually and the time of onset shows a downward trend in age. In the recent years, drug treatment has been applied in clinical to delay the bone mineral density (BMD) decrease. Thus the monitoring efficacy of drugs is becoming important. Dual energy X-ray absorptiometry (DXA) is the golden standard for diagnosing OP, however, the sensitivity and specificity are low due to variety of factors affected. Quantitative computed tomography (QCT) can measure BMD of actively metabolized cancellous bone free of interruption from adjacent tissue, and is highly sensitive to the treatment effects. The functional MRI (MRS, DWI, and DCE-MRI) and PET/CT can be used to non-invasively evaluate the vertebral bone marrow and microstructure pathophysiology changes through the parameters of fat fraction (FF), molecular motion of water, and marrow perfusion. In the present paper we main-ly reviewed the advantages of new imaging technologies in diagnosis and evaluating efficacy of drugs for treatment of OP.
Keywords：OsteoporosisDrug efficacyTomographyX-ray computedFunctional magnetic resonance imagingPositron emission tomography
Publication Date：2017-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：5( 547-551 )