Advancements in magnetic resonance imaging of cell apoptosis
ZHANG Hongchun
CAI Sainan
TAN Na
LIAO Haiyan
ZHOU Bing
WANG Guotao
XIA Xibin
Abstract：It is significant to detect apoptosis for detecting disease and assessing therapy efficiency at early stage. Recent years, many new MRI-based probes have improved the quality of MRI. Many small probes that target phosphatidylser-ine and demonstrate Caspase-3 activity are available to obtain superior tissue penetration. Molecular structures of many tra-ditional probes have been modified to improve the specific binding between probes and targets. A number of MRI-based probes, such as the Caspase-3 sensitive nano-aggregation MR probe (C-SNAM), have been used to improved signal strength of cell apoptosis in some degree.
Keywords：Apoptosis imagingMagnetic resonance imagingMolecular imagingPhosphatidylserineAnnexin VCaspase-3
Publication Date：2017-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 317-320 )