Application of multislice spiral CT pulmonary functional imaging in evaluation of pulmonary function in patients with asbestosis
LIANG Yin
Abstract：Objective To explore the characteristics of pulmonary function in patients with asbestosis at different stages and normal volunteers by using multislice spiral CT. Methods Twenty one asbestosis patients and 21 normal volunteers were selected from January 1, 2013 to December 31, 2015. The demographics including age, gender, contact, jobs and other basic information were collected. Paired inspiratory and expiratory multislice spiral CT scans were obtained from all subjects. Pulmonary volume indices and mean lung density indices were measured with Siemens Pulmo quantitative analysis software. Two independent samples t test was used to compare the differences of lung volume and lung mean density between patient and control groups. ANOVA with LSD post-hoc test was used to compare differences of the pulmonary function-indices between the control group and the different stages of asbestosis. Wilcoxon rank sum test and the Fisher's exact test were also used to compare the exposure history, the types of work at different stages of asbestosis. Results 1) The length of exposure time significantly differed beween Ⅰand Ⅱ stages, (Z=5.023, P<0.05), the longer occupational exposure, the higherprobability of developing disease stage Ⅱ. However, there was no significant difference in type of work between the two groups (P>0.05). 2) The inspiratory lung volume (Vin), left lung inspiratory volume (LVin), right lung inspiratory volume (RVin), and volume difference between Vin and expiratory lung volume (Vex) (Vin-Vex) in asbestosis patient group were significantly lower than that of control group, and the right lung Vex (RVex), and volume ratio (Vex/Vin) were significantly higher than that of control group (P<0.05). However, there was no significant difference in Vex and left lung Vex (LVex) between two groups (P>0.05). 3) The inspiratory mean lung density (MLDin), left lung MLDin (LMLDin), and right lung MLDin (RMLDin) were not significantly differences between the asbestosis patients and the controls (P>0.05). The expiratory mean lung density (MLDex), left lung MLDex (LMLDex), right lung MLDex (RMLDex), and density ratio (MLDex/MLDin) in asbestosis patients were significantly higher, but the density differences (MLDex-MLDin) was significantly lower than that of control group (P<0.05). 4) The RVex was significantly higher at asbestosis stageⅡthan stageⅠ or control group (P<0.05). The Vin-Vex at both diseaseⅠandⅡstage were significantly lower than that of the control group (P<0.05), and was significantly lower at stageⅡthan stageⅠ(P<0.05). There was no significant difference in the pulmonary volume indices and mean lung density indices among the three groups (P>0.05). Conclusions The characteristics of pulmonary function in asbestosis patients include the decreased total lung volume, left lung and right lung volume, and forced vital capacity , increased residual volume, left lung, and right lung residual volume, and emphysema formation. The longer the dust contact time, the more serious the disease. Multislice spiral CT pulmonary function imaging plays an important role in the evaluation of lung function in asbestosis patients.
Keywords：AsbestosisStageLung functionTomographySpiral computed
Publication Date：2017-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：5( 124-128 )