The effects of AQP4 gene silencing on brain edema and corresponding imaging changes
JIANG Xili
LU Hong
CHEN Jianqiang
XIE Shucai
Abstract：The mechanism of cerebral edema is complex. The intracellular Ca2+overload, free radical damage, and reduction of Na +~-K +~-ATPase activity in cell membrane are associated with the formation of brain edema, but these mechanisms hardly explain the occurrence of cerebral edema exactly. In recent years, the study of aquaporin4 (AQP4) at molecular level brings a breakthrough to make the mechanism of cerebral edema clear. A number of experimental studies have shown that AQP4 is closely related to the formation of cerebral edema. It has been reported that AQP4 gene silencing which reduces the expression of AQP4 can reduce the extent of brain edema. The purposes of this article were to explore the effects of AQP4 gene silencing on brain edema and corresponding imaging changes and to provide theoretical basis for the diagnosis and treatment of cerebral edema.
Keywords：Aquaporin-4Gene silencingRNA interferenceBrain edemaMagnetic resonance imaging
Publication Date：2016-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：5( 495-499 )