Diagnosis of non-obstructive hydrocephalus with quantitative phase-contrast MRI
TANG Min
YANG Meng
DENG Qinzhe
CHENG Miao
CHEN Sipan
LIU Peng
ZHANG Xiaoling
Abstract：Objebtive To discuss the application value of quantitative phase-contrast MRl in diagnosing non-obstructive hydrocephalus and cerebral small-vessel disease. Methods All subjects, including 11 cases of communicating hydrocephalus, six cases of normal-pressure hydrocephalus, nine cases of cerebral small-vessel disease, and 13 cases of healthy volunteers, underwent quantitative phase-contrast MRl. Cerebro-spinal fluid(CSF) velocity and flow volume were measured at the level of aqueduct of Sylvius. A SNK-q was used to compare the difference among the 4 groups. Results ①In all subjects, the CSF flow at the level of aqueduct of Sylvius was bidirectional. The velocity curve presented as"U" shape , maximum velocity of non-obstructive hydrocephalus was higher than those of the other groups, especially the maximum systolic velocity.②Maximum diastolic velocity showed statistically significant differences between groups of communicating hydrocephalus and normal pressure hydrocephalus, and between normal pressure hydrocephalus and cerebral small-vessel disease (P<0.05), and the values were significantly higher in all patients groups than the normal group. Maximum diastolic velocity statistically differed between non-obstructive hydrocephalus and cerebral small-vessel disease groups (P<0.05). The maximal diastolic velocity was significantly higher in normal-pressure hydrocephalus group than the normal group and group of cerebral small-vessel disease. The flow volume was significantly differed among the 4 groups (P<0.05), the net flow volume of non-obstructive hydrocephalus was negative, the flow volume of cerebral small-vessel disease group was lower than that of normal group. Conclusion PC-MRI could be used to diagnose non-obstructive hydrocephalus and differentiate it from cerebral small-vessel disease with similar imaging finding and clinical symptoms.
Keywords：HydrocephalusCerebral small-vessel diseaseMagnetic resonance imagingCine-phase contrast
Publication Date：2016-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 465-467,488 )