DCE-MRI for tumor microvessels in glioma:clinical applications and current progress
ZHANG Junfeng
LIU Heng
CHEN Xiao
ZHANG Weiguo
Abstract：Tumor microvessels play a crucial role in tumor igenesis and progression, clinical decision-making and prognosis prediction. Due to the disruption of blood brain barrier, conventional MRI characterized by contrast enhancement may not truely reflect dysfunction of tumor microvessels and can hamper the accuracy of diagnosis in glioma. Dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) is a functional MRI, it provides conventional morphological information, and derives as well tracer kinetic parameters to estimate permeability of tumor microvessels noninvasively in a dynamic and quantitative manner, and hence has received considerable attention in the research and clinical field. The purpose of this article was to review the clinical application of DCE-MRI for glioma and tumor microvessels, with emphasis on the correlation analysis between DCE-MRI and glioma-associated biomarkers, glioma grading, therapy monitoring and prognosis prediction.
Keywords：GliomaTumor microvesselsDynamic contrast-enhanced magnetic resonance imagingGlioma gradingAnti-angiogenesis therapy
Publication Date：2016-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：7( 366-372 )