Fat fraction value measured by proton magnetic resonance spectroscopy in osteoporosis：a Meta analysis
ZHANG Cici
SHEN Si
WANG Fei
QIU Lin
LIU Sirun
Abstract：Objective To have a systemic review of the association between fat fraction value measured by proton magnetic resonance spectroscopy and osteoporosis bone mineral density, and to explore if fat fraction can be a reliable indicator for the diagnosis osteoporosis like bone mineral density. Methods Pubmed, Cochrane library, Medline, and China National Knowledge Infrastructure (CNKI) datebases (from January, 2000 to December, 2014) were searched to collect articles about proton magnetic resonance spectroscopy assessing osteoporosis. The data of fat fraction in osteoporosis group and normal group and Pearson correlation coefficient between bone mineral density and fat fraction were extracted from the articles. Pooled weighted mean difference (WMD) and 95%confidence interval, Pearson correlation coefficient between bone mineral density and fat fraction were done using review manager 5. 0 software. Results Nine articles (seven English articles, two Chinese articles) were included with 499 cases (210 normal and 289 osteoporosis). The fat fraction value was higher in osteoporosis than normal (WMD 9.25, 95%CI:6.95 to 11.56). A negative correlation was found between fat fraction value and bone mineral density (-0.59,95%CI:-0.76~-0.42). Conclusion Fat fraction measured by Proton magnetic resonance spectroscopy has certain clinical value in the assessment of osteoporosis, it can be used as a supplemental examination of DXA. Whether it can be a reliable indicator for the diagnosis osteoporosis like bone mineral density, the feasibility and accuracy need more research.
Keywords：OsteoporosisMagnetic resonance spectroscopyBone mineral densityFat fractionMeta analysis
Publication Date：2015-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 409-412 )