A preliminary study on predicting the efficacy of neoadjuvant chemotherapy for cervical cancer with CT perfusion imaging
YIN Liang
GUO Shunlin
GUO Jigang
LEI Junqiang
GUO Qihong
Abstract：Objective To explore the value of CT perfusion imaging in predicting the efficacy of neoadjuvant chemotherapy for cervical cancer. Methods 31 cases with cervical cancer who underwent CT perfusion before neoadjuvant chemotherapy from 2012 March to 2014 July in First Hospital Affiliated to Lanzhou University were selected. All cases were divided into effective group (n=22, 70.97%) and ineffective group (n=9, 29.03%) according to the efficency of neoadjuvant chemotherapy. All dates were retrospective analyzed and the factors affecting the efficacy of neoadjuvant chemotherapy were investigated. Results Blood flow (BF), blood volume (BV), and permeability of the effective group were significantly higher than those of ineffective group (P＜0.05). The efficacy of neoadjuvant chemotherapy for cervical cancer was positively correlated with BF, BV, and permeability (r=0.290, P=0.020; r=0.364, P=0.003; r=0.565, P=0.000, respectively). The FIGO staging, histological type, pathological grade, and the maximum diameter of the tumors were not associated with efficacy of neoadjuvant chemotherapy (P＞0.05). Permeability was independent factor affecting the efficacy of neoadjuvant chemotherapy for cervical cancer and high permeability predicted high efficiency (AUC=0.897, P＜0.001, 95%CI, 0.774～0.992). Conclusion CT perfusion imaging is helpful in predicting the efficacy of neoadjuvant chemotherapy for cervical cancer.
Keywords：Cervical carcinomaTomographyX-ray computedPerfusionChemotherapyadjuvant
Publication Date：2015-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 205-208 )