KIBRA gene polymorphism in Alzheimer’s disease
ZHANG Ningnannan
ZHANG Zhang
Abstract：Genetic factor plays an important role in Alzheimer’s disease (AD). Recent studies demonstrated that the single nucleotide polymorphism in the kidney and brain (KIBRA) expressed protein gene linked to increased AD risk. The KIBRA gene, which related to late AD, has highly expressed in hippocampus in AD. However, functional MRI findings on the KIBRA genetic polymorphisms were inconsistent. The mechanisms of KIBRA gene polymorphism in AD were still unclear. The explore of KIBRA gene on AD brain functions together with the behavioral performance will fundamentally be the groundwork for early diagnostic of AD, and would provide important clues for early diagnosis and intervention for AD.
Keywords：KIBRA geneAlzheimer’s diseasePolymorphismHippocampusImaging genetics
Publication Date：2015-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 13-15,24 )