Proton MRS investigation of glutamate in Alzheimer’s disease
ZHANG Ningnannan
ZHANG Zhang
Abstract：The main clinical feature of Alzheimer’s disease (AD) is the progressive cognitive dysfunction. Proton magnetic resonance spectroscopy (1H-MRS) can be used to detect the abnormalities in anatomical structures and metabolite, which are related to the cognitive dysfunction in AD brains. Glutamate (Glu) is the excitatory neurotransmitter in central nervous system. The AD pathogenesis is associated with the disorder of Glu. The 1H-MRS is a useful non-invasive method to detect metabolites in brain. These metabolites, from 1H-MRS, can be used as an indicator for AD early diagnosis, and can be used to monitor the therapeutic effect as well.
Keywords：Alzheimer’s diseaseProton magnetic resonance spectroscopyGlutamateMetaboliteNeurochemical
Publication Date：2014-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 314-317 )