Progress of DTI research in rat with middle cerebral artery occlusion
CAO Chen
JIANG Lin
ZHANG Xuejun
Abstract：Rat stroke model with middle cerebral artery occlusion (MCAO) is easy, safe, and less affective to the nature progress of cerebral edema and intracranial pressure, and has been widely used in the study of cerebral ischemia. MCAO model has been used in studies with diffusion tensor imaging (DTI), which is enable assessment of the spatial and temporal patterns of functional and structural changes inside and outside ischemic areas in vivo to elaborate pathophysiological process after stroke. The traditional DTI allows estimation of the structural integrity and connectivity of white matter tracts. Some new DTI technologies, such as diffusion spectral imaging (DSI), the Q-ball imaging, and diffusion kurtosis imaging (DKI), extend the benefits of conventional DTI. Using these new imaging methods and the MCAO model provides a unique mean to discover the dynamic structural and functional changes after onset of stroke and to predict outcome and evaluate drug efficacy. This article outlines the methods and the latest progress of DTI and functional MRI based on the rat ’s MCAO model.
Keywords：RatMiddle cerebral artery occlusionDiffusion tensor imagingQ-space imagingDiffusion kurtosis imaging
Publication Date：2014-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 212-215 )