Pyroptosis in the Pathogenesis of Common Gynecological Diseases
HUANG Jing-ting
MA Li
YAO Bo
FENG Xiao-ling
Abstract：Pyroptosis is an inflammatory form of programmed cell death.The abnormal activation or inhibition of pyroptosis is closely associated with the occurrence of inflammatory diseases,autoimmune diseases,and tumors in gynecology.For instance,in gynecological inflammatory diseases,pathogen infection can activate intracellular inflammasomes,trigger pyroptosis,and release a large number of inflammatory factors that exacerbate the inflammatory response,leading to tissue damage and disease progression.In gynecological tumors such as endometrial carcinoma and cervical cancer,pyroptosis may serve as a defensive mechanism for the body to eliminate tumor cells.However,tumor cells may also evade pyroptosis through certain mechanisms,promoting their own proliferation and metastasis.The role of pyroptosis is also important in pregnancy-related diseases.The in-depth study on the role of pyroptosis in common gynecological diseases can provide new insights and potential targets for early diagnosis and treatment of the diseases.
Keywords：PyroptosisGenital diseasesfemaleGenital neoplasmsAbortionhabitualInflammasomeGasdermins
Publication Date：2026-01-15
Online Publishing Date：2026-03-19(First online date of this platform, not the publication date of the document)
Pages：6( 71-76 )