The Correlation between Th17/Treg Ratio Imbalance and Ovarian Aging
ZHANG Jun-rong
CHEN Qian-li
CHENG Xi
XU Yun-zhao
Abstract：Ovarian aging is divided into the physiological and pathological categories,characterized by decreased ovarian reserve function,reduced follicle numbers,and hormonal imbalances.Ovarian aging is associated with the risk of various chronic diseases.Research has found that immune imbalance plays a central role in ovarian aging,particularly the dysregulation of the ratio between helper T cell 17(Th17 cell)and regulatory T cell(Treg cell).The Th17/Treg balance is precisely regulated by inflammatory factors,nuclear factor-κB(NF-κB)pathway,and mammalian target of rapamycin(mTOR)pathway.Its imbalance exacerbates ovarian local inflammation and accelerates follicular depletion.Currently,intervention strategies targeting the Th17/Treg imbalance have made progress in the treatment of autoimmune diseases,providing new approaches for clinical intervention in ovarian aging.We review the critical role of Th17/Treg imbalance in ovarian aging,offering a theoretical basis for the formulation of immunotherapy strategies to postpone ovarian aging.
Keywords：Th17 cellsT-lymphocytesregulatoryImmunomodulationOvarian agingCellular imbalance
Publication Date：2026-01-15
Online Publishing Date：2026-03-19(First online date of this platform, not the publication date of the document)
Pages：6( 54-59 )