The Impact of Sperm DNA Fragmentation on Intrauterine Insemination Outcomes and Intervention Strategies
CHEN Jia-lang
ZHANG Yun-shan
WANG Guang-teng
PANG Ze-hui
Abstract：Intrauterine insemination(IUI)has become a first-line method of assisted reproduction,due to its simple operation and low cost.However,the success rate of IUI has been stagnant at 10%-15%for many years.Sperm DNA fragmentation(SDF)is an important indicator for evaluating sperm function,and its formation mechanism involves endogenous factors(such as oxidative stress,abnormal apoptosis,and abnormal chromatin remodeling)and exogenous factors(such as environment,lifestyle,and iatrogenic influences).The common SDF detection methods pose challenges to the interpretation of detection results due to their inconsistent critical values.The elevated SDF rate has a significant impact on IUI outcomes,including reduced fertilization rates,pregnancy rates,and increased the risk of adverse pregnancy outcomes.At present,the intervention strategies for high SDF rate include lifestyle adjustments,medication or surgical treatment,and rational selection of assisted reproductive technologies.Clinical recommendations include SDF testing for couples with repeated IUI failures or unexplained infertility,and individualized comprehensive treatment strategies to improve fertility outcomes.
Keywords：SpermatozoaDNA fragmentationInseminationartificialInfertilitymaleReproductive techniquesassistedPregnancy outcome
Publication Date：2026-01-15
Online Publishing Date：2026-03-19(First online date of this platform, not the publication date of the document)
Pages：5( 40-44 )