The Mechanism of High Fat Diet-Induced Sperm Morphological Abnormalities
SHI Xue-ying
YANG Jin-ji
FU Hao
HU Chun-xiu
Abstract：Sperm morphology is a key indicator for assessing male fertility.The abnormality of sperm morphology is closely associated with the reduced sperm motility,lower fertilization rate and male infertility.Long-term or excessive consumption of high fat diet can lead to obesity,metabolic disorders and hormonal imbalances,which is significantly correlated with abnormal sperm morphology.The potential mechanisms by which high-fat diet induces sperm morphological abnormality involve the multiple disruptions in the hypothalamic-pituitary-gonadal axis,aberrant sperm membrane lipid metabolism,cytoskeletal dynamic imbalance,oxidative stress,testicular microenvironment inflammation,and epigenetic modifications.Interventions such as adopting a Mediterranean diet pattern or supplementing with antioxidants(e.g.,vitamin C,coenzyme Q10)may ameliorate the high fat diet-induced abnormalities in sperm morphology and function.We review the recent advances in the potential mechanism of how high fat diet-induced sperm morphological abnormalities,providing clinically strategies based on dietary modification and antioxidant intervention.
Keywords：Diethigh-fatInfertilitymaleSpermatozoaTeratozoospermiaGlucagon-like peptide 1
Publication Date：2025-11-15
Online Publishing Date：2026-01-07(First online date of this platform, not the publication date of the document)
Pages：6( 490-495 )