The Mechanism of Active Components of Traditional Chinese Medicine in Treating Ovarian Cancer by PI3K/Akt Signaling
ZHANG Li-qian
LU Run-guo
WANG Yu
SHI Bai-chao
WU Xiao-ke
Abstract：Ovarian cancer(OC)is one of the common malignant tumors in women.Most of patients are diagnosed at the advanced stage due to its insidious onset,resulting in poor clinical treatment outcomes.Currently,the treatment of OC mainly relies on chemotherapy and surgery,but the chemotherapy resistance and adverse reactions remain the clinical challenge.Studies have shown that the abnormal expressions of multiple signaling pathways are related to the pathogenesis of OC,such as the abnormal activation of the phosphoinositide 3-kinase(PI3K)/protein kinase B(Akt)signaling pathway.The active components of traditional Chinese medicine can regulate the PI3K/Akt signaling pathway to inhibit the proliferation,invasion,migration and angiogenesis of OC cells,to promote the apoptosis of OC cells,and to improve the chemosensitivity of OC cells.This review summarizes the role of the PI3K/Akt signaling pathway in OC and the research progress on the mechanism of the active components of traditional Chinese medicine in regulating the PI3K/Akt signaling pathway,with the aim of providing a reference for the clinical application of traditional Chinese medicine in the treatment or adjutant therapy of OC.
Keywords：Ovarian neoplasmsAntineoplastic agents(TCD)Phosphatidylinositol 3-kinasesProto-oncogene proteins c-aktCell proliferationCell movementApoptosis
Publication Date：2025-09-15
Online Publishing Date：2025-10-30(First online date of this platform, not the publication date of the document)
Pages：7( 434-440 )