The Role of Triggering Receptor Expressed on Myeloid Cells-1 in Preeclampsia
YANG Qi
XU Rong-rong
CUI Hong-mei
Abstract：Preeclampsia(PE)is a common complication during pregnancy.The pathogenesis of PE is closely related to immune imbalance,inflammatory responses,and placental dysfunction.The triggering receptors expressed on myeloid cells-1(TREM-1)is an important pro-inflammatory receptor,widely expressed in neutrophils and mononuclear macrophages.TREM-1 plays a role in amplifying inflammatory responses in various inflammatory diseases.Studies have found that TREM-1 expression is significantly elevated in the peripheral blood and placental tissues of PE patients.It can activate nuclear factor-κB(NF-κB)and promote the release of cytokines through the multiple signaling pathways such as DNAX-associated protein 12(DAP 12),Toll-like receptor 4(TLR4),and nucleotide-binding oligomerization domain receptors(NLRs),thereby exacerbating inflammatory damage and endothelial dysfunction.TREM-1 may also serve as a potential biomarker for the early assessment of PE risk and severity.This review focuses on the structure of TREM-1,its signaling pathways and possible mechanisms in the development of PE,aiming to provide a theoretical basis for the early diagnosis and targeted intervention of PE.
Keywords：Pre-eclampsiaInflammationOxidative stressSignal transductionTriggering receptor expressed on myeloid cells-1
Publication Date：2025-09-15
Online Publishing Date：2025-10-30(First online date of this platform, not the publication date of the document)
Pages：5( 424-428 )