Effects of Per-and Polyfluoroalkyl Substances on Female Reproductive Health and Outcomes of Assisted Reproductive Technology
XIONG Min
YANG Dan-dan
CHAI Meng-han
ZHANG Qian-nan
ZHANG Zhi-guo
CHEN Bei-li
Abstract：Per-and polyfluoroalkyl substances(PFAS)exist in life area and consumer products,and enter the human body through breathing,diet,skin contact and other ways.PFASs cause the adverse consequence to female reproductive health.Studies have shown that PFAS can affect ovarian function by interfering with the endocrine axis,damaging mitochondria,inducing oxidative stress,disrupting gap junction communication,and regulating epigenetics,and resulting in reproductive toxicity,which is also related to many diseases of female reproductive system such as polycystic ovary syndrome,premature ovarian insufficiency,diminished ovarian reserve and endometriosis.In infertile people treated with assisted reproductive technology(ART),it was also found that the level of PFAS was negatively correlated with oocyte yield,the number of two pronuclei,and embryo quality,adversely affecting ART outcomes.We review the impact of PFAS on female reproductive health and ART outcomes,in order to provide a new evidence for the subsequent research.
Keywords：Fluorine compoundsReproductive healthReproductive techniquesassistedOvaryFemale urogenital diseases
Publication Date：2025-09-15
Online Publishing Date：2025-10-30(First online date of this platform, not the publication date of the document)
Pages：5( 411-415 )