Research Progress on 5-Hydroxytryptamin and Adverse Pregnancy Outcomes
LIU Yue
GAO Jing-shu
WANG Yu
FENG Jia-xing
GE Hang
WU Xiao-ke
Abstract：5-hydroxytryptamin(5-HT)as a neurotransmitter participates in the regulation of mood,appetite and blood circulation by the interaction with its receptors.5-HT also plays a significant role in maintaining placental function,oocyte maturation,and early embryonic development.Studies have shown that the abnormal level of 5-HT during pregnancy is closely associated with the adverse pregnancy outcomes such as hyperemesis gravidarum,pregnancy-induced hypertension,and gestational diabetes.The elevated level of the 5-HT3 receptor during pregnancy can increase the risk of nausea and vomiting of pregnancy or hyperemesis gravidarum.The abnormal levels of 5-HT1,5-HT2,and 5-HT7 receptors during pregnancy can raise the risk of pregnancy-induced hypertension and gestational diabetes.This article aims to elucidate the specific mechanisms that 5-HT affects the adverse pregnancy outcomes,and to provide new potential insights for the future clinical prevention and treatment of adverse pregnancy outcomes.
Keywords：SerotoninReceptorsserotoninHyperemesis gravidarumHypertensionpregnancy-inducedDiabetesgestational
Publication Date：2025-03-15
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：6( 155-160 )