Effect of Growth Factors in Follicular Fluid on Oocyte Development and Quality
WANG Yun-feng
HOU Hai-yan
WANG Jian-mei
Abstract：Follicular fluid is composed of the plasma that crosses the blood-follicle barrier and the active substances secreted by granulosa cells and theca cells.It contains various growth factors that significantly influence the development and quality of oocytes,including members of the transforming growth factor-βsuperfamily,insulin-like growth factors,tumor necrosis factor-α,vascular endothelial growth factors,interleukins(IL)and others.They regulate cell growth and function by binding to specific,high-affinity receptors of membrane,thereby affecting oocyte maturation and quality,as well as subsequent fertilization,embryonic development,and pregnancy outcomes.The concentrations of growth factors in follicular fluid may be related to oocyte quality.These factors such as bone morphogenetic protein-15(BMP-15),growth differentiation factor-9(GDF-9)and IL-6 have garnered significant attention.Although the relationship between growth factors and oocyte quality remains controversial,future research will reveal their exact connection,providing more accurate methods for predicting oocyte quality and embryonic development in clinical practice.
Keywords：Follicular fluidIntercellular signaling peptides and proteinsTransforming growth factor betaInterleukinsOocyte quality
Publication Date：2025-03-15
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：7( 137-143 )