Comparison of Two Frozen-Thawed Embryo Transfer Protocols for Infertile Patients with Endometriosis and Thin Endometrial
WANG Dong-xue
BAO Li-li
GAO Bing-qian
MA Xiao-fang
YANG Bo
Abstract：Objective:To compare the effects of two different frozen-thawed embryo transfer(FET)protocols on pregnancy outcomes in infertility patients with endometriosis and thin endometrial.Methods:A retrospective analysis was conducted on the clinical data of 200 cycles of endometriosis and thin endometrial patients who underwent FET assisted pregnancy for the first time in our hospital.According to the endometrial preparation regimens,they were divided into the GnRH-a-HRT group(D-HRT group,99 cycles)and the GnRH-a-OI group(D-OI group,101 cycles).The general informations,the regimens of endometrial,the indicators related to embryo and pregnance,and the outcomes of perinatal were compared between the two groups.Results:There were no statistically significant differences in the age,duration of infertility,body mass index(BMI),baseline hormones,anti-Müllerian hormone(AMH),carbohydrate antigen 125(CA125),antral follicle count(AFC),and the endometrial thickness on previous hCG days or transplant days between the two groups of patients(all P＞0.05).The E2 level before progesterone conversion in the D-OI group was significantly lower than that in the D-HRT group,and the endometrial thickness on the day of transplantation was significantly higher than that in the D-HRT group(both P＜0.05).There were no statistically significant differences in the treatment days,progesterone levels before progesterone conversion,number of transferred embryos,type of transferred embryos,rate of high-quality embryos,and implantation rate between the two groups(all P＞0.05).The early pregnancy loss rate and premature birth rate in the D-OI group were significantly lower than those in the D-HRT group,while the clinical pregnancy rate,sustained pregnancy rate,and live birth rate in the D-OI group were significantly higher than those in the D-HRT group(all P＜0.05).There were no statistical differences between the two groups in the ectopic pregnancy rate,twin pregnancy rate,gestational diabetes mellitus and hypertension rate,and neonatal malformation rate(all P＞0.05).Conclusions:The D-OI protocol for patients with endometriosis and thin endometrium in the FET cycles can improve their clinical pregnancy rate,sustained pregnancy rate,and live birth rate,reduce the early pregnancy loss rate and premature birth rate,suggesting the superiority over the D-HRT protocol.It is worthy of further clinical study.
Keywords：EndometriosisOvulation inductionHormone replacement therapyPregnancy rateThin endometriumLive birth rateFreeze-thawed embryo transfer
Publication Date：2025-01-14
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：6( 9-14 )