Association of Circadian Rhythm Disorders with Polycystic Ovary Syndrome
LEI Rui-xiang
WAN Yi
LI Yu-zi
GUAN De-feng
ZHANG Xue-hong
Abstract：Circadian rhythm adapt the body to the changes of external environment through physiological oscillations on a 24-h cycle,and play a role in regulating energy metabolism,inflammation,cell renewal,and gut microbiota.The dysfunction of circadian rhythm can lead to the reduction of fertility in women.Polycystic ovary syndrome(PCOS)is increasingly described as an inherited polygenic trait that manifests itself after exposure to poor lifestyle or environmental risk factors.Studies have shown that unhealthy dietary and sleep habits in modern lifestyles can contribute to the development of PCOS through circadian rhythm disorders.The mechanisms may involve the endocrine and reproductive imbalances(hyperandrogenism),metabolic alterations(insulin resistance,lipid metabolism abnormalities),disruption of the gastrointestinal microbiome(ecological dysregulation),and genetic factors.Genes that play an important role in the maintenance of circadian rhythm stabilization are known as biological clock genes,and may be novel targets for the prevention and treatment of PCOS.In this paper,we summarize the research on circadian rhythm disorders and the development of PCOS,and provide a reference for future research and clinical treatment.
Keywords：Polycystic ovary syndromeCircadian rhythmHyperandrogenismGastrointestinal microbiomeHeredity
Publication Date：2024-11-15
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：5( 501-505 )