Efficacy of Chinese Medicine Compound on Abnormal Glucose and Lipid Metabolism in Patients with Obese Polycystic Ovary Syndrome:A Meta Analysis
GAO Zheng
LI Meng-yuan
LI Bo
LIANG Jing-qiao
ZHANG Ya-dong
XU Xin
Abstract：Objective:To explore the efficacy and safety of traditional Chinese medicine(TCM)on the metabolic abnormalities in the patients with obese polycystic ovary syndrome(PCOS)through a Meta-analysis and literature review.Methods:The randomized controlled trials(RCTs)on the treatment of PCOS with TCM or/and the combination of TCM and western medicine(WM),and WM only as control,were searched by computer from the mainstream medical databases at home and abroad.The quality of the design scheme was evaluated by reference to the Cochrane Systematic Review manual,and Meta-analysis was performed by using RevMan 5.4 software.Results:In this study,22 RCTs were included for Meta-analysis.TCM or TCM plus WM was superior to WM alone not only in improving ovulation rate(P＜0.05),but also in improving homeostasis model assessment of insulin resistance(HOMA-IR),fasting insulin(FINS),body mass index(BMI),triglyceride(TG),total cholesterol(TC),low density lipoprotein(LDL),high density lipoprotein(HDL)and other aspects(all P＜0.05).However,there was no difference in the regulation of fasting blood glucose(FBG)and waist-to-hip ratio(WHR)in the TCM or TCM plus WM groups when compared with the WM alone group(both P＞0.05).Conclusions:TCM or TCM plus WM has better efficacy in the treatment of abnormal glucose and lipid metabolism in the patients with obese PCOS by multi-pathway and multi-target,without adverse outcomes,suggesting that TCM or TCM plus WM is superior to WM alone.
Keywords：Polycystic ovary syndromeChinese materia medicaIntegrated traditional Chinese medicine &western medicineObesityabdominalGlucose metabolism disordersLipid metabolism disordersMeta-analysis
Publication Date：2024-09-15
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：11( 368-377,394 )