Advancements of MiR-202 in Reproductive Modulation
LIANG Yue
DONG Jie
XIAO Xi-feng
WANG Xiao-hong
Abstract：MicroRNAs(miRNAs)have emerged as key regulators of diverse biological processes,including cell proliferation,differentiation,apoptosis,and metabolism.They are also actively involved in the reproductive and developmental processes of organisms.Among the let-7 family,miR-202 stands out owing to its high conservation across different species,implying the potential shared functions and regulatory roles.Substantial evidence from numerous studies underscores the involvement of miR-202 in a wide range of pathophysiological processes.Notably,it exerts significant inhibitory effects on tumor cell proliferation,migration,and invasion.Moreover,miR-202 plays a critical role in modulating the differentiation of T cell and exhibits the implications in the regulation of neurodevelopment and neurodegenerative diseases.The increasing evidence have indicated that miR-202 plays a crucial role in gamete development and the regulation of reproductive physiology.In this article,we review the regulatory roles of miR-202 in key reproductive processes,namely spermatogenesis,follicle development,and reproductive endocrine regulation.
Keywords：MicroRNAsSpermatogenesisSex differentiationGerm cellsmiR-202Reproductive modulation
Publication Date：2024-05-15
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：6( 228-233 )